Desalting and Buffer Exchange Market Size Analysis, Drivers, Restraints, Key Factors Forecast, 2022–2028

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The global desalting and buffer exchange market size was USD 827.05 Million in 2020 and is expected to register a CAGR of 10.3% during the forecast period.

The Desalting And Buffer Exchange Market had a valuation of USD 827.05 Million in 2020 and is projected to grow at a compound annual growth rate (CAGR) of 10.3% during the forecast period. The increasing demand for monoclonal antibodies, along with higher investments and research and development (RD) expenditure by pharmaceutical and biotechnology companies, as well as advancements in proteomics and genomics research, are expected to be the key drivers for the growth of market revenue in the coming years. Furthermore, the growing popularity and application of chromatography experiments in the chemical sector and rapid advancements in molecular chemistry are also anticipated to contribute to the market's revenue growth during the forecast period.

Desalting and buffer exchange are essential techniques used to separate larger molecules from smaller ones or to exchange the buffer system to a more suitable one for downstream applications. These methods primarily rely on gel filtration chromatography, which is a form of size exclusion chromatography. The objective of desalting and buffer exchange is to retrieve sample components in buffers that are used to pre-equilibrate small and porous polymer beads. Desalting is primarily performed to eliminate salts from protein solutions, phenol from nucleic acids, or excessive labeling reagents from conjugated proteins.

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Competitive Landscape:

The global desalting and buffer exchange market is highly fragmented owing to high number of regional and global players.

Key players are engaged in product development, strategic alliances, and expanding their product portfolio to cater to growing end-use demand and gaining a robust footing in the market.

Major companies operating in the market include Thermo Fisher Scientific, Inc., Merck AG, GE Healthcare, Danaher Corporation, Sartorius, Agilent Technologies, Inc., VWR International LLC, Bio-works Technologies AB, Bio-Rad Laboratories, and Norgen Biotek Corp.

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Driving Factors:

  1. Increasing Demand for Monoclonal Antibodies: The growing demand for monoclonal antibodies, which are widely used in therapeutics and diagnostics, is driving the need for desalting and buffer exchange methods. These techniques are crucial for purifying and optimizing the quality of monoclonal antibody preparations.
  2. Investment and RD Expenditure by Pharmaceutical and Biotechnology Firms: Pharmaceutical and biotechnology companies are investing heavily in research and development activities. This investment is driving the development of new drugs and biologics, which require desalting and buffer exchange techniques for purification and formulation processes.
  3. Progress in Proteomics and Genomics Research: Advances in proteomics and genomics research, which involve the study of proteins and genes on a large scale, are increasing the demand for desalting and buffer exchange methods. These techniques are essential for preparing samples and isolating specific molecules for analysis.
  4. Popularity and Application of Chromatography Experiments in the Chemical Sector: Chromatography experiments, including desalting and buffer exchange, are gaining popularity in the chemical sector. These techniques are used for purification, separation, and analysis of various chemical compounds, driving the demand for desalting and buffer exchange products and services.


  1. High Cost of Desalting and Buffer Exchange Methods: Desalting and buffer exchange techniques often require specialized equipment and consumables, which can be costly. The high cost of these methods may act as a restraint, particularly for smaller research laboratories or organizations with limited budgets.
  2. Technical Challenges and Complexities: Desalting and buffer exchange methods can be technically challenging and require expertise for optimal results. The complexity of these techniques may hinder their widespread adoption, especially in less-experienced laboratories or facilities without the necessary resources or knowledge.
  3. Limited Compatibility with Certain Sample Types: Some samples may not be compatible with desalting and buffer exchange methods due to their specific characteristics or compositions. This limitation can restrict the applicability of these techniques, particularly for samples with high salt concentrations, complex matrices, or unique chemical properties.
  4. Alternative Purification and Separation Techniques: There are alternative methods available for purification and separation, such as filtration, dialysis, and other chromatographic techniques. Depending on the specific requirements of a particular application, these alternatives may offer more suitable or cost-effective solutions, posing a challenge to the growth of the desalting and buffer exchange market.

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